BNP infusion during reperfusion increases cardiac triglyceride accumulation and decreases cardiac contractility after myocardial ischemia in pigs
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چکیده
Introduction: Chemotherapy induced mucositis (CIM) is a frequent complication to anticancer treatments. Glucagon-like peptide-2 (GLP-2) has been suggested for treatment of CIM, unfortunately the peptide is also shown to accentuate colonic dysplasia in carcinogen treated mice. Glucagon-like peptide 1(GLP-1) is secreted simultaneously with GLP-2 from the L-cell. GLP-1 is responsible for maintaining glucose homeostasis. Recently, an intestinal growth effect was discovered for GLP-1. Aim: The aim of this experiment was to elucidate if GLP-1 had a potential role in treating CIM. Methods: Mice were injected with 5-Fluorouracil (5-FU) or saline to induce mucositis and treated with a GLP-2 analogue, a GLP-1 analogue or vehicle. Mice were sacrificed 48 h after 5-FU injections. Endpoints were intestinal weight, villus height and histological scoring of mucositis severity. Rats were injected with 5-FU or saline and after 48 h blood was analysed for concentrations of GLP-1 and GLP-2. Results: Both peptides could significantly prevent the loss of mucosal mass and villus height and significantly decrease mucositis severity score in duodenum and jejunum. The effect was equivalent. GLP-1 and GLP-2 levels in blood were more than ten fold and seven fold increased respectively. Discussion: Both endogenous GLP-1 and GLP-2 were increased after intestinal injury, indicating an importance for the peptides for protection of the intestine. We found an equal effect of GLP-1 and GLP-2 in the treatment of CIM which opens up the possibility that mucositis as well as other acute intestinal disorders can benefit from treatment with GLP-1 analogues.
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تاریخ انتشار 2012